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Evidence is increasing that all addiction without exception is related to issues with the brain's reward center, especially the mesolimbic system. This part of the problem regulates reward responses in acquiring food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both after they malfunction and when they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in reply to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to shed pounds can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with weight reduction and the people who go through it you should err on the side of caution and let the FDA do its job and demand some study be done so your public is aware of the side effects and dangers of the medications before we drive them. Keep in mind that drug companies are in business to generate income and that they would say almost anything to keep people on their own medications.

Researchers found that participants taking this drug for the year, lost weight within one month and have kept the extra weight off through the entire 56 weeks with the study. Contrave is really a combination from the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs that are made up of many active ingredient, that might make them more potent and safer.

Combo-pilling will be the newest fad or in addition to this the newest ahead under scrutiny and thus it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills has become popular could be the fact that by right now there aren't long term prescription diet pills that have been approved by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be authorized by the FDA.

Seizures certainly are a side effect with Contrave and really should not be taken in those with seizure disorders. The drug may also raise blood pressure level and heartbeat, and shouldn't be used in people who have a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must not be used in patients with uncontrolled high blood pressure, and also by you aren't heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients having a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert medical professionals and patients towards the increased likelihood of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking.

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